Poly(ethylenimine) conjugated bioreducible dendrimer for efficient gene delivery
نویسندگان
چکیده
منابع مشابه
Bioreducible polyethylenimine nanoparticles for the efficient delivery of nucleic acids.
Recently, non-viral vectors for nucleic acid delivery have received considerable attention. Among the various non-viral vectors, branched polyethylenimine (bPEI, 25 kDa) has been one of the most widely used carrier systems due to its high transfection efficiency, however, it imparts high cytotoxicity. In this study, we have crosslinked bPEI with a bioreducible linker, 3,3'-dithiodipropionic aci...
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ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2015
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2015.11.005